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Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carci

Biochemical and Biophysical Research Communications

Biochemical and Biophysical Research Communications 342 (2006) 824-828

 

Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma


Qingyuan Zhang *, Xinmei Kang, Weihui Zhao

Department of Medical Oncology, Tumor Hospital of Harbin Medical University, Harbin, China

 

Abstract
Angiogenesis is now known to play an important role in both growth and metastasis of lung cancer. The intense interest in angiogenesis
has led to a re-examination of the activity of many established cytotoxic agents. Some results of recent experimental studies have
suggested that frequent administration of certain cytotoxic agents at low doses increases the antiangiogenic activity of the drugs. In the
present study, we investigated the efficacy of the combination of low-dose cyclophosphamide and ginsenoside Rg3 for the antiangiogenic
effect on Lewis lung carcinoma. Our findings suggest that continuous low-dose regimen of CTX increases the efficacy of targeting the
tumor microvasculature, which produces therapeutic activity with decreased toxicity. The effects of the low-dose schedule of CTX
may be further enhanced by concurrent administration of angiogenic inhibitor ginsenoside Rg3. As an antiangiogenic method, this regimen
has the advantage of a reduced susceptibility to drug resistance mechanisms and improved animal survival.

Keywords: Cyclophosphamide; Ginsenoside Rg3; Angiogenesis; Lung cancer; Chemotherapy

 

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